ProDesk-3D aims to develop and demonstrate a novel multi-process and multi-axis “self-sufficient” desktop machine (DeskMach) that will enable holistic processing of high-precision 3D micro-components by integrating micro-features onto their surfaces with minimal human intervention. This is achieved through a series of innovative concepts/approaches. i) the reconfigurability of ProDesk-3D is designed as a “slot-in” facility for transferring 3D parts in situ for different operations via an intelligent high-end controlling system, minimising part processing errors and idle manipulations. ii) a hybrid parallel kinematic multi-axis (6+2) part positioner acts as the “focal point” for the geometrical arrangement of “slot-in” facility posts, providing a compact configuration with low compound positioning errors. Iii) a “built-in” part and end-effector manipulation system, utilising a smart robotic arm and optimal geometrical arrangement of “slot-in facility posts,” reduces ancillaries and improves system compactness. iv) in-situ metrology, machine vision, and referencing systems for 3D printed parts and end-effectors ensure process compliance by detecting defects in real-time, improving part processing accuracy and reducing non-operational times. The resulting multi-functional parts will find applications across diverse medical, aerospace, electronics, instrumentation, and automotive industries.