LSAM-OPT project aims to revolutionize part design and manufacturing through the integration of large-scale additively manufactured components and thermoplastic resin-infused fibre reinforcement using advanced topology optimization techniques. Employing cutting-edge large-scale additive manufacturing technology (LSAM), the project focuses on enhancing the structural integrity and performance of parts by strategically pulling fibre reinforcements through printed structural cavities. The LSAM-OPT technology development will be fully exploited for the fabrication of high-end products in the aeronautics, automotive, and energy sectors. In LSAM-OPT we address the challenges of traditional composite manufacturing techniques by leveraging the scalability and design freedom of additive manufacturing. The integration between innovative design optimization and additive manufacturing processes will ensure robust and lightweight structural components that are durable and fully recyclable. The outcomes of this study have the potential to significantly improve the efficiency, sustainability, and economic viability of involved industrial sectors, contributing to the global transition towards cleaner and more sustainable design and manufacturing.