The general objective of the REMEDI project is to overcome the barriers related to Laser Metal Deposition (LMD) technology for digital manufacturing of high value-added meter-size components for the aerospace sector which prevent the wider market uptake. For that purpose, a Quality-by-Design (QBD) procedure using different CAx technologies will be developed by CT Ingenieros and AIMEN and deployed by manufacturing of zero-defect components for two different sectors: energy (end user ES) and aerospace (Coskunoz Aerospace) using two manufacturing facilities (Smarmec and Coskunoz R&D). These manufacturing lines will then be capable of replicating these successful case studies in any demanding industry. The above-mentioned QBD procedure will be accomplished by establishing a design chain consisting of: 1. design for mechanical resistance, based on topological optimization and structural integrity of layered-like DED parts; 2. design for manufacturability, based on the manufacturing constraints of the DED systems when designing a part; 3. design for heat management, by considering the outcome of the loop consisting of AM setup – path planning – thermal simulation during the part design (design by CAPP) and by using the data analytics from the inline control system to detect potentially conflictive design features (design by inline control).